Frequency of visceral leishmaniasis relapses in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy.

نویسندگان

  • Jose A Mira
  • Juan E Corzo
  • Antonio Rivero
  • Juan Macias
  • Fernando Lozano De Leon
  • Julian Torre-Cisneros
  • Jesus Gomez-Mateos
  • Rafael Jurado
  • Juan A Pineda
چکیده

There are contradictory data about whether highly active antiretroviral therapy (HAART) prevents visceral leishmaniasis (VL) relapses in human immunodeficiency virus type 1 (HIV-1)-infected patients. The aim of this study was to assess the frequency of VL relapses in individuals receiving HAART. Thirty-one patients who received HAART after developing VL were included in a retrospective cohort study. Ten of them received secondary chemoprophylaxis and the rest did not. Eight (38%) patients without secondary chemoprophylaxis showed a VL relapse. None of the seven subjects with VL relapses and 6 of 11 without recurrence (P = 0.038), in whom all scheduled data were available, showed an increase of more than 100 CD4+ cells/mm(3) during the follow-up. Patients with relapse showed higher levels of HIV RNA viral load at their last visit (P = 0.047). The frequency of VL relapses in patients receiving HAART is high. Relapses of VL are observed only in individuals with uncontrolled HIV replication and/or poor immunologic responses.

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عنوان ژورنال:
  • The American journal of tropical medicine and hygiene

دوره 70 3  شماره 

صفحات  -

تاریخ انتشار 2004